Adipocyte-Derived Amino Acid Storage Proteins are Required for Germline Stem Cell Maintenance in Adult Drosophila Females.

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Tissue homeostasis is dependent on precise coordination between endocrine organs in response to changes in organism physiology. Secreted circulating factors from adipocytes (called adipokines) regulate the behavior of stem cell lineages in peripheral tissues in multiple organisms. In addition to their endocrine roles, Drosophila adipocytes store and secrete amino acid storage proteins throughout development. During the larval feeding period, adipocytes secrete storage proteins into the hemolymph, which are reabsorbed by the adipose tissue during metamorphosis to control adult organ size and fertility. Despite the known functions for storage proteins during the larval stages, their requirement during Drosophila adulthood and reproduction are uncharacterized. We discover that adipocyte-specific knockdown of the storage proteins Larval serum protein 1 ( Lsp1 ) α/β/γ and Larval serum protein 2 ( Lsp2 ) results in a decrease in GSC maintenance. We further reveal that decreased GSC number is due to downregulation of Target of Rapamycin (TOR) signaling in GSCs, suggesting compromised amino acid sensing directly in GSCs. We also find that the proteins that mediate storage protein adipocyte reabsorption, Fat body protein 1 (Fbp1) and Fat body protein 2 (Fbp2), are expressed in ovarian follicle cells. Intriguingly, Fbp1 nor Fbp2 appear to be required in follicle cells for GSC maintenance

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

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