Adipose-derived stem cell uses in orthopaedic surgeries: a scoping review protocol.

Early human evidence such as case series or small samples is exploring possible benefits.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Background Musculoskeletal disorders represent a significant global health burden, frequently leading to chronic pain, functional impairment and disability. Conventional treatment modalities, including rehabilitation, pharmacotherapy and surgical intervention, are often associated with suboptimal outcomes and prolonged recovery. Adipose-derived stem cells (ADSCs) have gained considerable attention due to their regenerative capacity, accessibility and immunomodulatory properties. Preclinical studies of ADSCs have demonstrated promising effects in skeletal muscle regeneration. However, the evidence from human orthopaedic shoulder surgery remains inconclusive. This scoping review aims to map the process of adipose tissue-derived treatments in orthopaedic surgery, especially shoulder surgery. Methods and analysis A scoping review will be conducted using the Joanna Briggs Institute methodology to systematically map existing evidence on the clinical use of ADSCs in orthopaedic shoulder surgery. The search strategy will use the Population-Concept-Context framework and will be applied across four bibliographic databases (Embase, MEDLINE, CENTRAL and Scopus) and ClinicalTrials.gov, with additional grey literature searches. Studies will be limited to adults (≥18 years) undergoing shoulder surgery. Both clinical and patient-reported outcomes will be extracted. Article screening and data e

Evidence level

Early human evidence such as case series or small samples is exploring possible benefits.

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