Adipose tissue for reconstruction and wound healing: applications, challenges, and future directions.

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Adipose tissue has emerged as an important therapeutic resource in regenerative medicine due to its accessibility and its rich content of regenerative cells and bioactive factors. Adipose-derived products, including lipoaspirate, stromal vascular fraction (SVF), and adipose-derived mesenchymal stromal/stem cells (AD-MSCs), are increasingly used in clinical practice for tissue reconstruction, wound healing, and the treatment of complex tissue defects. In this review, we summarize current clinical applications of adipose tissue-based therapies, focusing on their role in tissue regeneration and wound management. We briefly discuss adipose tissue harvesting techniques and the biological characteristics of AD-MSCs relevant to their therapeutic use. Attention is given to clinical evidence regarding efficacy, safety, and translational challenges associated with SVF- and AD-MSC-based interventions. We highlight current limitations and future directions for the integration of adipose tissue-derived therapies into regenerative and reconstructive medicine.

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

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