SVF
Level B· Emerging Clinical EvidenceRandomized Controlled Trial

Alveolar Bone Graft Supplemented With Stromal Vascular Fraction in Patients With Permanent Dentition: A Randomized Study.

Kurimori KT., Bastos EO., Camara PRP., Mascarenhas Dias B., Uyeda GL., Alonso N.

Randomized Controlled Trial on Hip, published in Cleft Palate Craniofac J (2026) — summary generated from the PubMed abstract.

This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.

Study type
Randomized Controlled Trial
Journal
Cleft Palate Craniofac J (2026)
Country
United States
Reported sample size
—
PMID
39584372
DOI
10.1177/10556656241296711

Abstract (original English)

ObjectiveTo evaluate bone development in patients with alveolar clefts and permanent dentition treated with alveolar bone graft supplemented with stromal vascular fraction (SVF).DesignClinical, prospective, randomized.LocationSingle tertiary care institution.PatientsEighteen participants with unilateral alveolar cleft and permanent dentition were included. Patients with other comorbidities were excluded.InterventionThe control group underwent alveolar bone grafting (ABG) using iliac crest bone, while the experimental group underwent the same treatment, supplemented with SVF. Adipose tissue was collected by abdominal liposuction, and the SVF was processed using mechanical methods (decantation, microfragmentation, and filtration).Main Outcome MeasurementBone formation and bone graft integration rate in alveolar cleft at 6 months postsurgery using 3-dimensional tomographic methods and density measurements.ResultsThe amount of bone graft correlated with an improvement in the relationship between the cleft and noncleft sides (R = 0.78, P < .001) and an improvement in alveolar cleft density (R = 0.69, P = .005), but did not correlate with the graft integration rate. The experimental group showed larger cleft sizes (0.83 × 1.74 cm 3 , P = .021) and older patients (17.35 × 27.6 years, P = .002), and did not differ in terms of bone development variables when compared to the control grou

What this study does not prove

  • • This study does not prove SVF is an approved treatment or a replacement for standard care.

Evidence level

Several human studies exist, but sample sizes, methodology, or follow-up remain limited, so conclusions are not firm.

How we grade evidence
HumansFemaleMaleCleft PalateProspective StudiesAlveolar Bone GraftingTreatment OutcomeChildDentition, PermanentAdolescent
Hip
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