SVF
Level D· Preclinical EvidenceLaboratory Study

Anti-Obesity Effects of Pear Extract ( Pyrus pyrifolia ): Clinical Implications and Therapeutic Potential.

Roh YK., Ha YS., Kim TK., Kim K., Kim SR., Kim DH.

Laboratory Study on Systemic / IV, published in Int J Stem Cells (2026) — summary generated from the PubMed abstract.

This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.

Study type
Laboratory Study
Journal
Int J Stem Cells (2026)
Country
Korea (South)
Reported sample size
—
PMID
40808421
DOI
10.15283/ijsc25013

Abstract (original English)

Mitigating obesity is a pivotal strategy for addressing metabolic diseases, including cardiovascular diseases, liver diseases, and diabetes. Although pear extract exhibits various pharmacological effects in regenerative diseases, such as skin, nerve, and adipose tissue dysfunction, by eliminating excessive reactive oxygen species, its exact clinical role in obesity has not been well studied. In this study, we investigated the efficacy and safety of pear extract (UPhenon Ⓡ ), a dietary ingredient extracted from unripe pear ( Pyrus pyrifolia ), in Korean participants with obesity. The participants underwent a 12-week, randomized, double-blind placebo-controlled trial. Body fat mass, body weight, body mass index (BMI), and hematological and blood chemistry parameters were assessed. No adverse effects or significant changes were observed in the supplementation or placebo groups. Additionally, the two groups did not differ significantly in body fat mass, body weight, BMI, hematological parameters, or blood chemistry parameters, except for the liver-specific enzyme, aspartate aminotransferase. Interestingly, compared with the supplementation and placebo groups, after 12 weeks of pear extract administration, a significant decrease in aspartate aminotransferase levels was recorded, indicating that pear extract partially attenuates obesity-induced liver damage. Furthermore, when compare

What this study does not prove

  • • This study does not prove SVF is an approved treatment or a replacement for standard care.
  • • This is preclinical work; animal or laboratory results cannot be applied to humans.

Evidence level

Evidence comes from animal or laboratory studies and has not been confirmed in humans.

How we grade evidence
Systemic / IV
View on PubMedDOI

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