Application of Biocomposite Hydrogel With Developed Trabecular Cage in Lumbar Interbody Fusion: A Clinical Case Report.

Early human evidence such as case series or small samples is exploring possible benefits.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Background Lumbar interbody fusion (LIF) is a widely used surgical technique for treating degenerative spinal conditions. However, challenges such as pseudarthrosis and implant migration remain significant concerns. This case report presents the use of a novel trabecular titanium cage combined with a biocomposite hydrogel containing stromal-vascular fraction and BMP-2 to enhance osseointegration and accelerate bone fusion. Case presentation A 61-year-old female patient with severe chronic lumbar pain, functional impairment, and grade II anterolisthesis of L4 underwent lumbar interbody fusion. A custom-designed trabecular titanium cage was implanted, featuring an optimized porous structure for enhanced fixation and bone ingrowth. To further promote bone regeneration, a biocomposite hydrogel synthesized from adipose-derived stromal-vascular fraction and BMP-2 was applied. Postoperative assessment demonstrated significant pain reduction, improved functional activity, and early bone fusion formation. Radiological imaging confirmed stable implant positioning, progressive trabecularization, and successful osseointegration. No complications, such as implant migration or material loosening, were observed. Conclusions This case highlights the potential benefits of combining advanced implant design with bioactive materials in spinal fusion surgery. The approach resulted in early and stab

Evidence level

Early human evidence such as case series or small samples is exploring possible benefits.

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