Association between asprosin and metabolic syndrome in people living with human immunodeficiency virus: A case-control study

Early human evidence such as case series or small samples is exploring possible benefits.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

The lifespan of people living with human immunodeficiency virus (PLWH) has been extended following antiretroviral therapy, which, paradoxically, has increased the burden of metabolic syndrome (MS). Asprosin has emerged as a novel biomarker strongly associated with MS and other metabolic indicators. This study aimed to investigate the relationship between serum asprosin levels and MS in PLWH. This prospective case-control study enrolled 111 PLWH with MS and 111 PLWH without MS as controls. A 1:1 propensity score matching was performed to adjust for potential confounding factors, including age and antiretroviral therapy regimen. Serum asprosin levels and other clinical variables were measured. PLWH with MS exhibited significantly higher serum asprosin levels compared to those without MS (19.2 [14.2-24.4] vs 15.4 [11.4-18.1] ng/mL, respectively, P < .001). Multivariate logistic regression analysis confirmed that elevated serum asprosin levels (odds ratios = 1.239, 95% confidence interval: 1.063-1.445, P = .006) were associated with MS in this population. Notably, the use of integrase strand transfer inhibitors was associated with the highest serum asprosin levels, followed by non-nucleoside reverse transcriptase inhibitors and protease inhibitors (17.8 [13.3-21.8] vs 16.6 [10.5-22.9] vs 16 [12, 18.7] ng/mL, respectively, P = .006). Sensitivity analyses confirmed the robustness of

Evidence level

Early human evidence such as case series or small samples is exploring possible benefits.

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