Biological Therapy for Avascular Necrosis of Femoral Head - A Case Report

Early human evidence such as case series or small samples is exploring possible benefits.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Introduction Avascular necrosis (AVN) of the femoral head is a type of osteonecrosis with the disruption of blood supply to the head of the femur. Management of AVN femoral head depends on the stage of the disease. In this case report, we elaborated on the biological therapy for bilateral AVN of the femoral head. Case report A 44-year-old male presented with pain in both hips for 2 years with a history of rest pain in both hips. Radiologically, the patient was diagnosed with bilateral AVN of the femoral head. The patient was offered bone marrow aspirate concentrate (BMAC) in the right femoral head, followed up for 7 years, whereas the adult autologous live cultured osteoblasts in the left femoral head, followed up for 6 years. Conclusion Biological therapy with differentiated osteoblasts remains a viable option for AVN femoral head when compared with an undifferentiated BMAC cocktail.

Evidence level

Early human evidence such as case series or small samples is exploring possible benefits.

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