Brown adipose tissue engineering: advances, challenges, and future directions.
Karanfil AS., Louis F., Matsusaki M.
Narrative Review on Systemic / IV, published in Trends Biotechnol (2026) — summary generated from the PubMed abstract.
This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.
- Study type
- Narrative Review
- Journal
- Trends Biotechnol (2026)
- Country
- England
- Reported sample size
- —
- PMID
- 41006179
- DOI
- 10.1016/j.tibtech.2025.08.010
Abstract (original English)
Obesity is a major health issue as it increases the risk of developing chronic diseases, including cardiovascular disorders, diabetes, and certain types of cancer. Brown adipose tissue (BAT) is a promising target for obesity treatment due to its ability to burn fat and create heat via non-shivering thermogenesis. The development of BAT models for therapeutic use has become possible through recent advances in tissue engineering, including stem cell-based methods, 3D bioprinting, and organoid systems. However, optimizing differentiation protocols while maintaining the physiological relevance of BAT remains challenging. This review explores current advances in BAT engineering and highlights future research priorities for achieving clinical applications in metabolic health interventions.
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • This is a narrative review: it collects no new patient data and does not systematically appraise evidence quality.
Evidence level
There is currently not enough data to draw conclusions about benefit or risk for this topic.
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