Ca²⁺ signaling and the Hippo pathway: Intersections in cellular regulation

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

The Hippo signaling pathway is a master regulator of organ size and tissue homeostasis. Hippo integrates a broad range of cellular signals to regulate numerous processes, such as cell proliferation, differentiation, migration and mechanosensation. Ca 2+ is a fundamental second messenger that modulates signaling cascades involved in diverse cellular functions, some of which are also regulated by the Hippo pathway. Studies published over the last five years indicate that Ca 2+ can influence core Hippo pathway components. Nevertheless, comprehensive understanding of the crosstalk between Ca 2+ signaling and the Hippo pathway, and possible mechanisms through which Ca 2+ regulates Hippo, remain to be elucidated. In this review, we summarize the multiple intersections between Ca 2+ and the Hippo pathway and address the biological consequences.

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

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