Can a combination of nanofat and freeze-dried human amniotic membrane enhance full-thickness wound healing? An animal study using rabbit models.

Several human studies show positive signals, while research methods and sample sizes continue to develop.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Previous studies have explored nanofat stimulating tissue regeneration and maturation, promoting remodeling through its rich content of growth factors and stem cells; however, comprehensive data on its use in full-thickness wounds remains limited. The aim of this study was to evaluate the effectiveness of combining nanofat with freeze-dried human amniotic membrane (FDHAM) for treating full-thickness wounds in a rabbit model. An animal experimental study using a post-test control group design was conducted. Thirty-six male New Zealand white rabbits ( Oryctolagus cuniculus ) were randomly assigned to two groups: the experimental group (received a combination of nanofat and FDHAM) and the control group (received FDHAM alone). Each group was subdivided to evaluate effects on days 3 and 7. Macroscopic evaluations of wound healing, microscopic assessment of epithelialization and measurement of epidermal growth factor (EGF) levels in the wounds were conducted on days 3 and 7 post-injury. The present study indicated that the combination treatment significantly elevated EGF levels in the wounds on both days 3 and 7 (with p < 0.001 for both assessment time points). The combination of nanofat-FDHAM did not significantly accelerate epithelialization on either day 3 or 7. This study highlights that combining nanofat with FDHAM did not significantly speed up epithelialization of full-thickne

Evidence level

Several human studies show positive signals, while research methods and sample sizes continue to develop.

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