Level C· Early human research exploring benefitsCase Report / SeriesEurope PMCOpen access

A Case of Mandibular Osteomyelitis Occurring in a Patient With Parry-Romberg Syndrome

Koguchi-Yoshida R., Tayama M., Kaneko H., Watanabe H., Iimura T., Maruoka Y.

Case Report / Series on Autoimmune Research, published in Cureus (2025) — summary generated from the PubMed abstract.

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Level C· Early human research exploring benefitsEvidence level of this study

Early human evidence such as case series or small samples is exploring possible benefits.

  • Level A · Stronger Clinical Evidence
  • Level B · Emerging clinical evidence with positive signals
  • Level C · Early human research exploring benefits
  • Level D · Scientific groundwork from lab and animal studies
  • Emerging · Emerging topic under active research
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This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.

Study type
Case Report / Series
Journal
Cureus (2025)
Reported sample size
—
Source database
Europe PMC
PMID
41527610
PMCID
PMC12790632
DOI
10.7759/cureus.99021

Abstract (original English)

Progressive hemifacial atrophy, also known as Parry-Romberg syndrome (PRS), is an idiopathic disorder characterized by progressive unilateral facial depression caused by atrophy of the skin and subcutaneous tissue. We present a case of mandibular osteomyelitis occurring in a patient with this condition, together with a review of the literature. The clinical findings in this case suggest that autoimmune disease and trauma are involved in contributing factors to disease progression. Possible involvement of neurovascular and neuroskeletal dysregulations in the pathogenesis of PRS is also discussed.

What this study does not prove

  • • This study does not prove SVF is an approved treatment or a replacement for standard care.
  • • Without an adequate control group, treatment effects cannot be separated from other factors.

Evidence level

Early human evidence such as case series or small samples is exploring possible benefits.

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