Case Report: Allogeneic adipose-derived mesenchymal stem cells for severe feline chronic kidney disease.

Early human evidence such as case series or small samples is exploring possible benefits.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

A 10-year-old neutered male Ragdoll cat presented with symptoms of anorexia, nausea, vomiting, lethargy, and progressive weight loss. Laboratory parameters and clinical signs led to a diagnosis of International Renal Interest Society (IRIS) Chronic Kidney Disease (CKD) Stage III. Following basic supportive therapy, clinical symptoms subsided, and the patient was discharged for home management. Three months later, the cat's condition worsened, and upon reassessment, it met the diagnostic criteria for IRIS CKD Stage IV. After 4 months of guideline-directed supportive care (in accordance with IRIS recommendations), there were no significant changes in clinical symptoms or laboratory markers, and the cat continued to exhibit a cachectic condition. Subsequently, allogeneic adipose-derived mesenchymal stem cell (AD-MSCs) therapy (2 × 10 6 cells/kg) was initiated via intravenous (IV) infusion, administered weekly for three consecutive weeks. No adverse events, such as fever or vomiting, were observed during or after therapy. Prior to AD-MSCs therapy, the cat's serum creatinine (SCr), blood urea nitrogen (BUN), and phosphorus (P) levels were all above the normal reference ranges. Three weeks after the final of the three AD-MSC treatments, the SCr level had returned to the reference range for CKD Stage II, while BUN and P levels showed an improving trend. The cat's mental status and app

Evidence level

Early human evidence such as case series or small samples is exploring possible benefits.

Browse all related research

Filter the research library by this study's title keywords, author, or publication year.