SVF
Level A· Stronger Clinical EvidenceSystematic Review

Cell therapy in tendon disorders: what is the current evidence?

Obaid H., Connell D.

Systematic Review on Tendon Injury, Rotator Cuff, Chronic Wound, published in Am J Sports Med (2010) — summary generated from the PubMed abstract.

This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.

Study type
Systematic Review
Journal
Am J Sports Med (2010)
Country
United States
Reported sample size
—
PMID
20699425
DOI
10.1177/0363546510373574

Abstract (original English)

Various types of tissue-derived cells are being experimented with for the treatment of tendinopathy, tendon repair, and use in tissue engineering. The aim of this systematic review is to explore the current evidence with a view to evaluate the potential of this therapeutic intervention. Systematic review. A review of the literature was conducted using PubMed. Search criteria included keywords "tendinopathy," "tendinitis," "tendinosis," "epicondylitis," "stem cell," and "cell therapy." Articles not written in English language were excluded. A total number of 379 articles were identified and a critical appraisal of the relevant articles was undertaken, which encompassed human and animal research. The review included articles related to various tissue-derived cells such as tendon progenitors, adipose tissue, synovium, muscle, bone marrow, and skin. The utility of cell therapy in tissue engineering and rotator cuff repair was also assessed. With the limitation of the available evidence, the literature suggests that cell therapy is applicable and may be effective for the treatment of tendinopathy. However, further research into the precise biological mechanisms, long-term implications, and cost-effectiveness is needed.

What this study does not prove

  • • This study does not prove SVF is an approved treatment or a replacement for standard care.

Evidence level

Relatively higher-quality human studies compared with other topics in this database, e.g. multiple RCTs or systematic reviews. This does not mean it is standard or approved care.

How we grade evidence
Cell- and Tissue-Based TherapyEvidence-Based MedicineHumansStem Cell TransplantationTendon InjuriesWound Healing
ShoulderArm & ElbowTendon InjuryRotator CuffChronic Wound
View on PubMedDOI

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