Cerium Phosphate Nanoparticles: Synthesis, Characterization, Biocompatibility, Regenerative Potential, and Antioxidant Activity

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

The aim of this study was to synthesize, characterize, and investigate the biomedical effects of nanoscale cerium phosphate obtained via different synthesis techniques, as well as to evaluate the influence of various CePO 4 concentrations on cells involved in skin structure regeneration (human mesenchymal stem cells, keratinocytes, and fibroblasts) and establish their antioxidant properties. Methods and Results: Cerium(III) orthophosphate was obtained by precipitation with ammonium dihydrogen phosphate from a nitrate solution. By changing the initial concentrations of the solutions and the drying and annealing temperatures, the best conditions for obtaining nanosized phosphate powders were established. The structure of rhabdophane was obtained by X-ray diffraction analysis, and the particle sizes were measured by transmission electron microscopy. The particle sizes ranged from 2 to 10 nm in the transverse direction and 20 to 50 nm in the longitudinal direction. Studies on cell lines have shown a high level of safety, as well as the regenerative potential of CePO 4 nanoparticles, which have a stimulating effect on the proliferation of MSCs at concentrations of 10 -2 to 10 -3 M for 48 h after application and stimulate the metabolism of human keratinocytes and fibroblasts at a wide range of concentrations (10 -3 to 10 -5 M). A dose-dependent antioxidant effect of small CePO 4 nano

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

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