SVF
Level D· Preclinical EvidenceAnimal Study

The Chinese herbal formular Kang Shuai Lao Pian enhances health status for skin, adipose-derived stem cells, intestinal microbes and metabolites in naturally senescent mice.

Li M., Yan Z., Hua W., Gong S., Wang Y., Chen H.

Animal Study on Skin Aging, published in J Ethnopharmacol (2026) — summary generated from the PubMed abstract.

This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.

Study type
Animal Study
Journal
J Ethnopharmacol (2026)
Country
Ireland
Reported sample size
—
PMID
41161627
DOI
10.1016/j.jep.2025.120807

Abstract (original English)

Aging is a time-dependent decline in physiological function that reduces quality of life. In traditional Chinese medicine (TCM), aging is viewed as "deficiency" complicated by blood stasis and qi stagnation. "Kang Shuai Lao Pian" (KSLP) is a Ming Dynasty herbal formula widely used to repenish qi, nourish yin, calm the heart, and tranquilize the mind. We aimed to evaluate the systemic anti-aging activity of KSLP and to determine its mode of action in naturally senescent mice. Male 16-18-month-old mice received daily intragastric gavage of KSLP (450 mg/kg) for 8 weeks. Skin structure, adipose distribution, neurotransmitters, adipose-derived stem cells (ADSCs) morphology and differentiation, 16S rRNA gene sequencing and untargeted metabolomics analysis of cecal feces were assessed. RNA sequencing (RNA-Seq) was performed on senescent ADSCs; metabolic-microbe correlations were analyzed by Pearson correlation. KSLP restored skin structure and dermal collagen density, normalized dopamine, norepinephrine, acetylcholine, and 5-hydroxytryptamine levels, and improved ADSCs osteogenic/adipogenic capacity- changes mechanistically linked to PI3K-Akt and cytokine-cytokine receptor interaction signaling pathways. In gut, KSLP reversed age-associated shifts in Firmicutes, Epsilonbacteraeota, Ruminococcaceae, and Helicobacter and modulated 57 metabolites particularly within amino acid, fatty aci

What this study does not prove

  • • This study does not prove SVF is an approved treatment or a replacement for standard care.
  • • This is preclinical work; animal or laboratory results cannot be applied to humans.

Evidence level

Evidence comes from animal or laboratory studies and has not been confirmed in humans.

How we grade evidence
AnimalsMaleGastrointestinal MicrobiomeDrugs, Chinese HerbalMiceStem CellsSkinAgingHealth StatusAdipose Tissue
Systemic / IVSkin Aging
View on PubMedDOI

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