SVF
Level A· Stronger Clinical EvidenceSystematic Review

Clinical Applications of Autologous Fat Grafting in Pathological Hand Conditions.

Thakker A., Mohamadzade N., Gnany J., Venkataram A., Abdelrahman M.

Systematic Review with a reported sample of 7 on Osteoarthritis, Scar, published in J Hand Surg Asian Pac Vol (2026) — summary generated from the PubMed abstract.

This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.

Study type
Systematic Review
Journal
J Hand Surg Asian Pac Vol (2026)
Country
Singapore
Reported sample size
7
PMID
41508623
DOI
10.1142/S2424835526500098

Abstract (original English)

Background: Autologous fat grafting (AFG) is increasingly explored beyond cosmetic applications, with interest in its regenerative potential for hand conditions such as cutaneous systemic sclerosis, thumb base osteoarthritis, Dupuytren contracture, burn scars, trauma and congenital hand deformities. This systematic review evaluates the therapeutic efficacy, techniques and outcomes associated with AFG across pathological hand conditions. Methods: A systematic literature search was conducted in July 2023 using PubMed, Ovid MEDLINE, Embase and Web of Science. Studies were included if they involved autologous fat or stromal vascular fraction (SVF) grafting for therapeutic purposes in hand conditions. Risk of bias (RoB) was assessed using RoB 2.0 for randomised controlled trials (RCTs) and the MINORS tool for non-RCTs. Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed throughout. Results: Twenty-five studies were included (8 RCTs, 17 non-RCTs), involving a total of 909 patients. Conditions studied included systemic sclerosis ( n = 7 studies), thumb base osteoarthritis ( n = 7), Dupuytren contracture ( n = 6), burn-related scars ( n = 2), hand trauma ( n = 2) and congenital deformities ( n = 2). AFG was most consistently associated with improvements in pain (visual analogue scale [VAS]), joint mobility (range of motion) and functiona

What this study does not prove

  • • This study does not prove SVF is an approved treatment or a replacement for standard care.

Evidence level

Relatively higher-quality human studies compared with other topics in this database, e.g. multiple RCTs or systematic reviews. This does not mean it is standard or approved care.

How we grade evidence
HumansAdipose TissueDupuytren ContractureTransplantation, AutologousOsteoarthritisHand InjuriesHand Deformities, CongenitalScleroderma, SystemicHandCicatrix
ShoulderSystemic / IVOsteoarthritisScar
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