[Clinical research progress of mesenchymal stem cells in treatment of chronic wounds].

Several human studies show positive signals, while research methods and sample sizes continue to develop.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

To review the clinical research progress of mesenchymal stem cells (MSCs) in the treatment of chronic wounds. The literature related to the chronic wound repair with MSCs at home and abroad in recent years was extensively reviewed, and the possible mechanism of MSCs in the treatment of chronic wounds, as well as its application and existing problems were summarized. MSCs can participate in all aspects of chronic wound healing to promote wound healing, and has shown broad application prospects in clinical trials. MSCs commonly used in clinical research include bone marrow-derived MSCs, adipose-derived tissue MSCs, and umbilical cord-derived MSCs. MSCs treatment is a promising strategy for the chronic wounds, but there are still many problems in its widespread clinical application that require further research. 综述 MSCs 在慢性创面治疗中的临床研究进展。. 广泛查阅近年来 MSCs 治疗慢性创面的相关文献，对 MSCs 治疗慢性创面的可能机制及其在临床慢性创面治疗中的应用情况、面临问题进行总结。. MSCs 可参与到慢性创面愈合各个环节来促进创面愈合，在临床试验中展现出广阔应用前景。目前临床研究常用的 MSCs 包括骨髓来源 MSCs、脂肪来源 MSCs 及脐带来源 MSCs。. MSCs 治疗慢性创面是一种具有前景的策略，但广泛应用于临床前还存在许多问题需进一步研究。.

Evidence level

Several human studies show positive signals, while research methods and sample sizes continue to develop.

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