Comparative Efficacy and Safety of Fractional CO₂ Laser and Gold Microneedling Radiofrequency for Atrophic Acne Scars: A Systematic Review

Relatively higher-quality human studies compared with other topics in this database, e.g. multiple RCTs or systematic reviews. This does not mean it is standard or approved care.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Background Acne is a prevalent dermatological disorder that profoundly affects patients' quality of life, frequently resulting in both physical discomfort and psychological distress. Conventional treatments, including topical agents, oral medications, and chemical peels, are primarily designed to alleviate symptoms but may be insufficient in effectively addressing persistent acne scars. Recent innovations in therapeutic technologies, such as microneedling radiofrequency (RF) and fractional carbon dioxide (CO 2 ) laser, have demonstrated significant potential in enhancing skin regeneration and improving the aesthetic appearance of acne scars. Materials and methods Microneedling RF operates by generating mechanical microinjuries in conjunction with RF energy, thereby stimulating dermal remodeling and collagen synthesis. In contrast, fractional CO 2 laser creates precisely controlled microthermal zones that facilitate wound healing and promote the regeneration of new tissue. This review critically examines the clinical efficacy of these two modalities, exploring their individual mechanisms and comparing treatment outcomes. Additionally, the potential synergistic effects of combining these technologies are discussed. Results Both microneedling RF and fractional CO 2 laser have demonstrated clinical efficacy in treating acne scars. The treatment outcomes, however, may vary depending

Evidence level

Relatively higher-quality human studies compared with other topics in this database, e.g. multiple RCTs or systematic reviews. This does not mean it is standard or approved care.

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