Level C· Early human research exploring benefitsRetrospective StudyEurope PMCOpen access

A comparative study of the clinical value of PRP and microfracture techniques in the repair of rotator cuff injuries

Li S., Lan Q., Liu X., Zhan Y., Kang Q., Zheng J.

Retrospective Study with a reported sample of 142 on Cartilage Damage, Tendon Injury, Rotator Cuff, Chronic Wound, published in J Orthop Surg Res (2026) — summary generated from the PubMed abstract.

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Level C· Early human research exploring benefitsEvidence level of this study

Early human evidence such as case series or small samples is exploring possible benefits.

  • Level A · Stronger Clinical Evidence
  • Level B · Emerging clinical evidence with positive signals
  • Level C · Early human research exploring benefits
  • Level D · Scientific groundwork from lab and animal studies
  • Emerging · Emerging topic under active research
Read the A–D evidence level guide

This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.

Study type
Retrospective Study
Journal
J Orthop Surg Res (2026)
Reported sample size
142
Source database
Europe PMC
PMID
42002765
PMCID
PMC13273990
DOI
10.1186/s13018-026-06831-2

Abstract (original English)

Objective To compare the clinical value of platelet-rich plasma (PRP) therapy versus microfracture technique in rotator cuff repair. Methods A retrospective study included 142 patients undergoing rotator cuff repair surgery, divided into PRP, microfracture, and control groups. Postoperative tendon-bone union, shoulder function scores (ASES, UCLA), pain scores (VAS), and complication rates were compared across groups. Results Baseline characteristics were comparable across groups. Both PRP and microfracture techniques effectively promoted tendon-bone healing and improved shoulder function, outperforming the control group. Safety profiles were equivalent between the two intervention groups. However, early VAS scores indicated higher pain levels in the microfracture group compared to both the PRP group and control groups. Conclusion Both PRP and microfracture techniques demonstrate sound clinical utility and safety in rotator cuff repair. PRP yields milder early postoperative pain, while microfracture offers cost advantages. Clinicians may tailor intervention choices based on individual patient factors including pain tolerance and financial circumstances.

What this study does not prove

  • • This study does not prove SVF is an approved treatment or a replacement for standard care.
  • • Without an adequate control group, treatment effects cannot be separated from other factors.

Evidence level

Early human evidence such as case series or small samples is exploring possible benefits.

How we grade evidence
Rotator CuffHumansPain MeasurementTreatment OutcomeRetrospective StudiesWound HealingAdultAgedMiddle AgedFemale

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