A Comprehensive Review of Honey-Containing Hydrogel for Wound Healing Applications

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Honey has long been recognized for its medicinal properties, particularly in wound healing. Recent advancements in material science have led to the development of honey-containing hydrogels, combining the natural healing properties of honey with the versatile characteristics of hydrogel matrices. These hydrogels offer numerous advantages, including high moisture retention, biocompatibility, and the controlled release of bioactive compounds, making them highly effective for wound healing applications. Hydrogels hold significant potential in advancing medical applications, particularly for cutaneous injuries. The diverse properties of honey, including antimicrobial, anti-inflammatory, and anti-eschar effects, have shown promise in accelerating tissue regeneration. According to studies, they are effective in maintaining a good swelling ratio index, Water Vapour Transmission Rate (WVTR), contact angle, tensile and elongation at break, in vitro biodegradation rate, viscosity and porosity analysis, lowering bacterial infections, and encouraging rapid tissue regeneration with notable FTIR peaks and SEM average pore sizes. However, limitations such as low bioavailability and inefficiencies in direct application reduce their therapeutic effectiveness at the wound site. Integrating honey into hydrogels can help preserve its wound healing mechanisms while enhancing its ability to facilita

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

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