Effect of Adipose Stem Cells Injection on Type VII and VIII Collagen Expression of Wistar Rat's Gingiva.

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Aims This study investigated the effect of injection of adipose stem cells (ASCs) on the expression of type VII and VIII collagen in Wistar rat's gingiva. Adipose stem cells can modulate the immune system, angiogenesis, wound healing, and extracellular matrix (ECM) remodeling. Materials and methods Ten Wistar rats aged three months were divided into two groups: the treatment group and the control group. The Wistar's gingival sulcus between the two incisor teeth was wounded with curettage. In the control group, PBS 1 × 10 6 was injected, meanwhile, the treatment group was injected with ASCs 1 × 10 6 , then the Wistar rats were terminated on the 14th day and the expression of type VII and VIII collagen was observed, and examined using the immunohistochemical method. Results In Wistar rats injected with ASCs, collagen VIII increased more than type VII collagen. Conclusion Adipose stem cells can increase the expression of collagen VIII compared to collagen VII. Clinical significance Adipose stem cells can influence collagen VII and VIII expression because ASCs release growth factors to restore damaged tissue. Collagen VIII increased more than type VII collagen because type VIII collagen contains integrin receptors, which aid in extracellular protein matrix interactions. Adipose stem cells have multiple signal recognition molecules on the cell membrane, which can be used as potentia

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

Browse all related research

Filter the research library by this study's title keywords, author, or publication year.