The effects of adipose-derived mesenchymal stem cells combined with sodium selenite on Hashimoto's thyroiditis.

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Recent research found that sodium selenite (Na 2 SeO 3 ) could ameliorate oxidative damage in patients with Hashimoto's thyroiditis (HT). Additionally, the effects of adipose-derived mesenchymal stem cells (AMSCs) in an animal model of HT were also reported. However, the effects of AMSCs combined with Na 2 SeO 3 on HT are unknown. We investigated the combined effects of AMSCs and Na 2 SeO 3 in a rat model of HT and the in vitro effect of Na 2 SeO 3 on AMSCs using gene microarray analyses. In the HT rat model, the combination of AMSCs and Na 2 SeO 3 restored thyroid tissue structure to that of normal controls and increased the levels of most antioxidant and inflammatory cytokines examined, but decreased the levels of interleukin 10 (IL-10) in HT thyroid tissues. At 0.5-20 µM, Na 2 SeO 3 promoted AMSC growth and increased the levels of reduced glutathione and total antioxidant capacity in AMSCs ( P <0.05). Na 2 SeO 3 increased the levels of hepatocyte growth factor (HGF), transforming growth factor beta (TGF-β), and stem cell factor (SCF) in AMSC culture supernatants. The results of the gene microarray analyses showed that the expression levels of certain genes involved in mitosis, DNA replication and repair, ubiquitination, synthesis and metabolism, and mitochondrial transport changed in response to Na 2 SeO 3 treatment. In conclusion, the combination of AMSCs and Na 2 SeO 3 res

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

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