SVF
Level A· Stronger Clinical EvidenceSystematic ReviewEurope PMCOpen access

Effects of advanced glycation end products (AGEs) on the differentiation potential of primary stem cells: a systematic review

Xu K., Zhang L., Yu N., Ren Z., Wang T., Zhang Y.

Systematic Review on Chronic Kidney Disease, Chronic Inflammation, published in Stem Cell Res Ther (2023) — summary generated from the PubMed abstract.

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Level A· Stronger Clinical EvidenceEvidence level of this study

Relatively higher-quality human studies compared with other topics in this database, e.g. multiple RCTs or systematic reviews. This does not mean it is standard or approved care.

  • Level A · Stronger Clinical Evidence
  • Level B · Emerging clinical evidence with positive signals
  • Level C · Early human research exploring benefits
  • Level D · Scientific groundwork from lab and animal studies
  • Emerging · Emerging topic under active research
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This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.

Study type
Systematic Review
Journal
Stem Cell Res Ther (2023)
Reported sample size
—
Source database
Europe PMC
PMID
37038234
PMCID
PMC10088298
DOI
10.1186/s13287-023-03324-5
Citations
17

Abstract (original English)

The formation and accumulation of advanced glycation end products (AGEs) have been associated with aging and the development, or worsening, of many degenerative diseases, such as atherosclerosis, chronic kidney disease, and diabetes. AGEs can accumulate in a variety of cells and tissues, and organs in the body, which in turn induces oxidative stress and inflammatory responses and adversely affects human health. In addition, under abnormal pathological conditions, AGEs create conditions that are not conducive to stem cell differentiation. Moreover, an accumulation of AGEs can affect the differentiation of stem cells. This, in turn, leads to impaired tissue repair and further aggravation of diabetic complications. Therefore, this systematic review clearly outlines the effects of AGEs on cell differentiation of various types of primary isolated stem cells and summarizes the possible regulatory mechanisms and interventions. Our study is expected to reveal the mechanism of tissue damage caused by the diabetic microenvironment from a cellular and molecular point of view and provide new ideas for treating complications caused by diabetes.

What this study does not prove

  • • This study does not prove SVF is an approved treatment or a replacement for standard care.

Evidence level

Relatively higher-quality human studies compared with other topics in this database, e.g. multiple RCTs or systematic reviews. This does not mean it is standard or approved care.

How we grade evidence
Stem CellsHumansDiabetes MellitusCell DifferentiationReceptor for Advanced Glycation End ProductsGlycation End Products, Advanced
Systemic / IVChronic Kidney DiseaseChronic Inflammation
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