Encapsulation of Adipose-Derived Stem Cells in Collagen-Based Hydrogel: Regenerative Therapy for Burn Wound Healing.

Relatively higher-quality human studies compared with other topics in this database, e.g. multiple RCTs or systematic reviews. This does not mean it is standard or approved care.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Introduction Skin graft is still the major treatment for burn injuries, despite its high risk of visible scarring which raises concerns regarding aesthetics and patient quality of life. This study proposes the usage of adipose-derived stem cells encapsulated in type I collagen-based hydrogel as a promoter to enhance wound healing, replace skin, and perfect skin regeneration. One of the potential tools for reconstructive surgery, regenerative treatments, and aesthetic enhancements due to their safety, efficiency, and cost-effectiveness is adipose-derived stem cells. Methods This review study used a systematic review approach and adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guideline, encompassing preparation, execution, and reporting phases. Results Based on the study result, adipose-derived stem cells had the potential as adjuvant therapy in the burn recovery process. Application of adipose-derived stem cells enhances tissue regeneration after burn injury by reducing inflammation, stimulating blood vessel growth, releasing growth factors, and developing into various cell types upon appropriate stimulation. To maximize its potential, this modality is constructed in a collagen-based hydrogel which allows greater cell retention and engraftment, regardless of the complex microenvironment of the wound. Topical administration applied as the wound

Evidence level

Relatively higher-quality human studies compared with other topics in this database, e.g. multiple RCTs or systematic reviews. This does not mean it is standard or approved care.

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