SVF
Level A· Stronger Clinical EvidenceSystematic Review

Exosomes in Skin Rejuvenation: Systematic Review of Anti-Aging Effects and Clinical Applications.

Alzahrani A., Alghamdi S., Alahmadi M., Alhussaini S., Alamry L., Alrashoud J.

Systematic Review on Chronic Wound, Skin Aging, published in Dermatol Pract Concept (2026) — summary generated from the PubMed abstract.

This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.

Study type
Systematic Review
Journal
Dermatol Pract Concept (2026)
Country
Austria
Reported sample size
—
PMID
41912205
DOI
10.5826/dpc.1601a6462

Abstract (original English)

Exosomes, tiny extracellular vesicles (EVs) from different cell types, are gaining attention in dermatology due to their unique properties. They enhance cell communication, transport bioactive substances, and influence immune responses, making them valuable for skin regeneration, wound healing, and addressing skin conditions. This systematic review explored current evidence regarding the efficacy, safety, and mechanisms of exosomes in skin rejuvenation. The search strategy included several databases: PubMed, Google Scholar, MEDLINE, Wiley, Web of Science, and EBSCO. The search for PubMed, MEDLINE, Wiley, Web of Science, and EBSCO used keywords: (Exosomes) AND (Skin Rejuvenation OR Skin Aging OR Skin Wrinkles), with MEDLINE limited to title-only searches. Google Scholar utilized broader terms: (Exosomes) OR (Extracellular Vesicles) OR (Exosomes Secreted by Human Circulating Fibrocytes) AND (Skin Rejuvenation OR Skin Wrinkles OR Skin Aging OR Skin Elasticity). Of the 1032 papers extracted through the database search, 21 articles were considered suitable for the systematic review. The reviewed studies consistently demonstrated that EVs and exosome-based therapies significantly improve skin elasticity, reduce wrinkle depth, enhance hydration, and modulate pigmentation. These effects were supported by molecular evidence showing increased collagen and elastin synthesis, reduced oxida

What this study does not prove

  • • This study does not prove SVF is an approved treatment or a replacement for standard care.

Evidence level

Relatively higher-quality human studies compared with other topics in this database, e.g. multiple RCTs or systematic reviews. This does not mean it is standard or approved care.

How we grade evidence
Face & SkinChronic WoundSkin Aging
View on PubMedDOI

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