Fabrication and application of microencapsulated adipose-derived mesenchymal stem cells /conductive nanofiber composite wound dressing.

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Wound healing is a complex and critical physiological process. Traditional cell transplantation strategies often fail to ensure long-term cell survival owing to the detrimental effects of the wound microenvironment, such as acidity, hypoxia, and nutrient deficiency. Therefore, encapsulating cells within microcapsules before transplantation to the wound site is highly desirable. In this work, a core-shell conductive nanofiber membrane with favorable mechanical properties was integrated with conductive microcapsules loaded with adipose-derived mesenchymal stem cells (ADSCs) to create an ADSCs delivery system, resulting in a microencapsulated ADSCs/conductive nanofiber composite dressing. Both the conductive nanofibers and microcapsule materials exhibited a porous, breathable structure. The core-shell conductive nanofibers showed excellent porosity, hydrophilicity, and in vitro degradation properties. Furthermore, the composite dressing exhibited good biocompatibility and antibacterial properties. Electrical stimulation in vitro effectively promoted the paracrine activity of the ADSCs within the microcapsules, preserving their viability and stemness. In vivo experiments revealed that the composite dressing group exhibited a significantly enhanced wound contraction compared to the control group, with the neoepidermis at the wound site more closely resembling the normal skin structu

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

Browse all related research

Filter the research library by this study's title keywords, author, or publication year.