Factors affecting cell viability and the yield of adipose-derived stromal vascular fraction.

Early human evidence such as case series or small samples is exploring possible benefits.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

The stromal vascular fraction (SVF) is isolated from adipose tissue and has tremendous regenerative potential for proliferation and differentiation. This study aimed to investigate the factors affecting the cell yield and viability of the SVF to improve the outcomes of its clinical applications and enhance its clinical usage. We performed a retrospective analysis with 121 patients who underwent liposuction to harvest adipose-derived SVF. We recorded patient demographic and clinical characteristics, including age, sex, body mass index (BMI), blood type, medical comorbidities, and smoking and alcohol consumption. As for operative variables, we noted the amount of lipoaspirate and the donor areas, including the lower and entire abdomen. The viability and the cell count of SVF were documented. Sex was a statistically significant factor for viability rate ( p < 0.015) and cell count ( p < 0.009). Men had higher viability, while women had higher cell counts. We found a statistically significant difference in the presence of hypertension ( p = 0.024) and alcohol consumption ( p = 0.024). There was a statistically significant relationship between cell count and age ( p < 0.001), BMI ( p = 0.006), and amount of lipoaspirate ( p < 0.001). Sex had significant associations with cell count and viability, while age, BMI, and lipoaspirate amount were significantly associated with cell count.

Evidence level

Early human evidence such as case series or small samples is exploring possible benefits.

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