Level B· Emerging Clinical Evidence
Stromal Vascular Fraction Therapy for Knee Osteoarthritis: A Systematic Review
Goncharov E.N., Koval O.A., Bezuglov E.N., Montemurro N.
Screened 172 articles and included 22; most reported safety and improved clinical outcomes, but designs varied widely.
- Study type
- Systematic Review
- Journal
- Medicina (Kaunas) (2023)
- Country
- Russia / Italy
- Sample size
- —
- Follow-up
- Varied across included studies
- PMID
- 38138193
- DOI
- 10.3390/medicina59122090
What was studied
Collated SVF studies for knee osteoarthritis published between 2017 and 2023.
Methods
- • Searched PubMed, Medline and Scopus for SVF, knee osteoarthritis and regenerative medicine.
Key findings
- • Most studies reported improved clinical outcomes and minimal adverse events.
- • Reviewers stressed that differences in sample size and design require cautious interpretation.
Limitations
- • No quantitative meta-analysis was performed.
- • Most included studies lacked rigorous control groups.
What this study does not prove
- • This study does not prove SVF is an approved treatment or a replacement for standard care.
- • Limited follow-up cannot indicate long-term outcomes.
Clinical interpretation
A useful overview of knee SVF literature, but not a substitute for RCT evidence.
Evidence level: Emerging Clinical Evidence