[The hopes of the mesenchymal stem cells in regenerative medicine].

Several human studies show positive signals, while research methods and sample sizes continue to develop.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

The mesenchymal stem cells are a cell population of bone marrow, which have the capacity to differentiate towards all the cells from the locomotor apparatus. They also have immunomodulatory properties and can contribute to tissue repair, thanks to the secretion of many growth factors. Such cells are also found in the cord blood. In the same way, very close stem cells exist in great quantity in fat tissue. These cells are very good candidates in regenerative medicine. Besides, several clinical trials were carried out in order to highlight their effectiveness mainly in osseous repair and also during hematopoietic stem cells graft or cardiac repair after infarction. However, these trials will be able to develop fully only with the condition that culture techniques meeting the conditions of good manufacturing practice are set-up. This presentation gives a progress report on the whole of these subjects.

Evidence level

Several human studies show positive signals, while research methods and sample sizes continue to develop.

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