Human Wharton's jelly mesenchymal stem cells protect neural cells from oxidative stress through paracrine mechanisms

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Aim Mesenchymal stem cells (MSCs) have neuroprotective and immunomodulatory properties, which are partly mediated by extracellular vesicles (EVs) secretion. We aimed to evaluate the effects of human Wharton's jelly-derived MSCs (WJ-MSCs) and their EVs on rat hippocampal cultures subjected to hydrogen peroxide (H 2 O 2 ). Materials & methods Hippocampal dissociated cultures were either co-cultured with WJ-MSCs or treated with their EVs prior to H 2 O 2 exposure and reactive oxygen species levels and cell viability were evaluated. Results Coculture with WJ-MSCs or pre-incubation with EVs prior to the insult reduced reactive oxygen species after H 2 O 2 exposure. Cell viability was improved only when coculture was maintained following the insult, while EVs did not significantly improve cell viability. Conclusion WJ-MSCs have potential antioxidant and neuroprotective effects on hippocampal cultures which might be partially mediated by EVs.

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

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