SVF
Level C· Early Human ResearchCohort Study

Implantation of autologous strip- and columnar-shaped adipose grafts for enhanced wound healing.

Zhu J., Chang D., Liu J., Peng M., Zhu Y., Tang J.

Cohort Study on Chronic Wound, Burns, Scar, published in Int J Artif Organs (2026) — summary generated from the PubMed abstract.

This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.

Study type
Cohort Study
Journal
Int J Artif Organs (2026)
Country
United States
Reported sample size
—
PMID
42124484
DOI
10.1177/03913988261429906

Abstract (original English)

This cohort study compared split-thickness skin graft transplantation and dispersed implantation of autologous strip skin (ASS) grafts combined with small autologous columnar skin (SCS) grafts for the treatment of small-area deep burn wounds. The experimental group was treated with dispersed implantation of ASS grafts combined with SCS grafts, whereas the control group underwent split-thickness skin graft (STSG) transplantation. The graft survival rate was significantly greater in the experimental group ( p < 0.0001). The time to complete epithelialization was similar for both groups ( p = 0.6626). The ratio of the donor site area to the wound area was lower ( p = 0.0002), and the healing time for the donor site was shorter in the experimental group ( p < 0.0001). Additionally, the Vancouver Scar Scale (VSS) scores for both the donor and recipient sites were significantly lower in the experimental group ( p < 0.0001, p = 0.0075). The combined implantation of ASS and SCS grafts effectively promoted the healing of small-area third-degree burn wounds, with good preservation of hair follicles and sebaceous glands. This method reduces wound contraction and damage to the donor site, with no significant lamellate scar hyperplasia observed during long-term follow-up, making it a viable alternative to split-thickness skin graft transplantation.

What this study does not prove

  • • This study does not prove SVF is an approved treatment or a replacement for standard care.

Evidence level

Early human evidence such as case series or small samples, often without a control group.

How we grade evidence
BurnsSkin TransplantationHumansWound HealingTransplantation, AutologousMaleAdipose TissueGraft SurvivalFemaleAdult
Hair & ScalpChronic WoundBurnsScar
View on PubMedDOI

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