In-situ fabrication of Quercus Infectoria-loaded bacterial cellulose-collagen composite for potential wound dressing materials.

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

This study investigates the fabrication of bacterial cellulose (BC)-collagen hydrolysate (CH) composite films with Quercus infectoria (QI) extract for potential wound dressing applications. The prepared materials were characterized for their morphology, swelling ratio, mechanical strength and antibacterial activity and cytocompatibility. The addition of CH (2 % w/v) significantly enhanced BC production (8.15 ± 0.39 g/L dry weight), improving mechanical strength, such as tensile strength (46.3 MPa), elongation at break (35.1 %), and swelling ratio (2515 % ± 75 %), compared to the control. FTIR analysis confirmed the successful incorporation of CH and QI into the BC matrix, with shifts in amide bands and the appearance of new peaks indicating QI integration. SEM images also showed that CH and QI made BC's fibrous structure denser and less porous. Although QI slightly reduced mechanical strength, it markedly improved antibacterial activity against S. aureus and E. coli. Human adipose-derived stem cells (hADSC) assays showed enhanced viability in BC/CH2% and BC/CH2%/QI1% composites with no significant cytotoxic effects after 24 h. Fluorescent staining confirmed hADSC survival and proliferation. These findings suggest that the BC/CH/QI composites provide a favorable microenvironment for tissue regeneration and hold strong potential for skin wound healing. Further physicochemical ana

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

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