Incisional Hernia Development: Wound Healing Gone Wrong?

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Incisional hernia (IH) is a common complication of abdominal surgeries, characterised by the protrusion of abdominal contents through a weakened surgical scar. Despite advancements in surgical techniques and biomaterials, IH remains a significant clinical and economic burden, with recurrence rates reaching up to 32% after repair. This unusually high number, despite many years of research focused on the improvement of surgical techniques, requires a better understanding of the potential origins of IH occurrence. This must implicate the tissues involved in scar formation of the abdominal wall for a better understanding of how these tissues are affected by the incision and what can potentially affect the most optimal wound healing. This work aimed to provide a comprehensive summary of the current knowledge regarding the ultrastructure of the abdominal wall and how incisions affect its mechanical integrity.

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

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