Limb saving with regenerative medicine tactics - a case report.

Early human evidence such as case series or small samples is exploring possible benefits.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Regenerative medicine has gained significant attention due to its diverse strategies for tissue restoration and restructuring. This therapeutic approach combines knowledge from cellular biology, tissue engineering, and translational medicine, providing new hope for treating conditions that previously lacked definitive therapeutic options. Although natural tissue regeneration occurs in some organs, such as the liver, and in superficial epidermal injuries, this process is limited. Tissue regeneration involves replacing damaged cells with cells of the same type, fully restoring tissue structure and function, while healing often results in scar tissue that may not have the same functional properties. Given this limitation, regenerative medicine aims to enhance the body's regenerative capacity. The manipulation of growth factors, such as platelet-derived growth factor and vascular endothelial growth factor, has been shown to increase vascularization and cell proliferation. Autologous fat grafting has emerged as a vital tool in regenerative medicine, demonstrating efficacy in promoting tissue regeneration due to its rich composition of mesenchymal stem cells and growth factors. Case studies illustrate that lipografting can improve wound healing in patients with chronic ulcers and contribute to aesthetic and functional outcomes in breast reconstruction. This study reports a case of a

Evidence level

Early human evidence such as case series or small samples is exploring possible benefits.

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