The mediating effect of BMI in serum vitamin D related sleep deprivation based on the NHANES database

Early human evidence such as case series or small samples is exploring possible benefits.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Background Sleep deprivation are a widespread condition globally, posing significant risks to individuals' physical and mental health. Existing studies have explored the associations between sleep deprivation, vitamin D, and obesity. However, there is limited research on the combined effects of serum vitamin D and obesity. To address this gap, we conducted a cross-sectional study using the NHANES database to investigate the mediating role of BMI in serum vitamin D-related sleep deprivation among Americans. Methods Our study included 20,865 participants from the NHANES database (2007-2018, 2021-2023). Logistic regression was utilized to assess the relationship between vitamin D levels and sleep deprivation. Mediation analysis was performed to examine the role of obesity in the association between vitamin D and sleep deprivation. Results Increased vitamin D levels coupled with a BMI below the 75th percentile significantly reduced the risk of sleep deprivation to 0.70 times (95% CI: 0.64-0.77; p 33.1 kg/m 2 ). Serum vitamin D showed a direct significant effect on reducing sleep deprivation risk ( β total = 1.92*10 -3 , P dir β indir = 7.59*10 -5 , P indir 75% group, the VD Sufficient and BMI Conclusion This study demonstrates that in American adults, vitamin D can influence sleep deprivation both directly and indirectly through its impact on BMI. Therefore, for individuals sufferi

Evidence level

Early human evidence such as case series or small samples is exploring possible benefits.

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