Mesenchymal Stem Cell Exosomes Therapy for Acquired Trichorrhexis Nodosa: A Case Series

Early human evidence such as case series or small samples is exploring possible benefits.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Background Recent preclinical studies have demonstrated the potential efficacy of stem cell exosomes in the treatment of hair loss. However, there is a paucity of clinical studies investigating the application of exosomes for this purpose. This case series presents three patients treated with exosomes for acquired trichorrhexis nodosa (ATN), a condition characterized by hair shaft abnormalities and breakage. Objectives This study aims to evaluate the effectiveness and safety of utilizing mesenchymal stem cell (MSC) exosomes as a novel therapeutic approach for the management of ATN. Methods A standardized process was employed to prepare 0.1 mL of exosomes, which were subsequently injected into bilateral regions of the patients' scalps at 0.5-1 cm intervals on a monthly basis. Each injection comprised a total volume of 5 mL, and all three patients underwent a minimum of four treatment sessions. The comparative efficacy of the treatment was evaluated using clinical photographs, dermatoscopy, and scanning electron microscopy (SEM) for all three patients post-intervention. Results The hair condition of the three patients demonstrated significant improvement, characterized by increased length and density, enhanced pigmentation with a reduced presence of dusty white dots, and the disappearance of dermoscopic black dots and broken hairs. SEM analysis revealed a remarkable recovery in t

Evidence level

Early human evidence such as case series or small samples is exploring possible benefits.

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