Multifunctional hydrogels for synergistic therapy of cutaneous melanoma-associated tumor recurrence and wound regeneration

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Cutaneous melanoma is a highly aggressive malignant tumor originated from melanocytes, and its postoperative recurrence and metastatic risk seriously threaten patient survival. Traditional treatments like surgical resection and chemoradiotherapy can merely control the disease in the short term, which faces severe limitations such as immunosuppression of tumor microenvironments (TME), drug resistance and systemic toxicity. Local recurrence, wound infection, and slow healing are common challenges in melanoma post-operation. In recent years, synergistic therapeutic strategies based on multifunctional hydrogels have been at the forefront of research due to their exceptional biomaterial properties, such as high biocompatibility, programmable drug release and tissue regeneration support. Different types of complexes are utilized to synthesize multifunctional hydrogels in different oncology therapeutic application scenarios, and various novel preparation processes and powerful functional components are introduced. Hydrogels have the ability to achieve responsive-triggered precision drug delivery, forming a synergistic system in immunotherapy, radiotherapy and phototherapy, reverse the inhibitory TME, and exert powerful anti-tumor effects through multiple signaling pathways. In addition, its improved hydrophilicity and biomimetic microcellular structure could accelerate postoperative w

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

Browse all related research

Filter the research library by this study's title keywords, author, or publication year.