Novel Role of Human Epicardial Adipocyte-Derived SPARCL1 in Postoperative Atrial Fibrillation Following Cardiovascular Surgery.

Early human evidence such as case series or small samples is exploring possible benefits.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Postoperative atrial fibrillation (POAF) is associated with short- and long-term morbidity and mortality. However, the ability of the epicardial adipocyte to regulate POAF remains poorly understood. The authors investigated the possible role of human epicardial adipocyte-derived adipokines in the regulation of the myocardial redox state and POAF. The authors prospectively studied 274 patients who underwent scheduled open-heart surgery. Finally, 149 patients without known atrial fibrillation were enrolled and divided into POAF and non-POAF groups. Epicardial adipose tissue biopsies and isolated preadipocytes were used to explore the important secretable adipokines associated with POAF. POAF occurred in 53 (35.6%) patients. Genome-wide expression profiling of background-matched differentiated preadipocytes representing the POAF or non-POAF groups and quantitative polymerase chain reaction validation as a biological replicate using all cohort samples revealed that only SPARCL1 was significantly downregulated in the POAF group. SPARCL1 messenger RNA expression in differentiated preadipocytes correlated with SPARCL1 protein concentration in the preadipocyte culture medium. SPARCL1 attenuated angiotensin II-induced oxidative stress in neonatal rat myocytes. Coculture of human induced pluripotent stem cell-derived atrial cardiomyocyte with the differentiated preadipocyte revealed that

Evidence level

Early human evidence such as case series or small samples is exploring possible benefits.

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