Omentum-Derived Mesenchymal Stem Cells Promote Antibacterial Effects and Protect Endothelial Functions via PAI-1.

Early human evidence such as case series or small samples is exploring possible benefits.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Surgical site infection increases the risk of morbidity and mortality in patients; among them, aortic graft infections present a poor prognosis. Previous clinical studies have demonstrated the efficacy of omentum flaps, a type of adipose tissue containing mesenchymal stem cells, in inhibiting SSI development in cardiothoracic surgery. However, how omental tissues prevent bacterial infection is still under investigation. Although mesenchymal stem cell is a type of cells that are reported to possess the ability to control infection, most studies have used mesenchymal stem cells derived from bone marrow or subcutaneous adipose tissues and the antibacterial properties of those derived from omentum (oAT-MSC) are still obscured. In the present study, we found that conditioned media (CM) derived from oAT-MSC possessed the ability to impair the growth of S. aureus and MRSA strains, similar to those derived from mesenchymal stem cells of subcutaneous adipose tissue. In addition, concentrated CM from oAT-MSC protected endothelial cells, preserving their morphology and functionality and reducing intracellular ROS following bacterial exposure. Furthermore, in a mouse infection model with S. aureus, concentrated CM from oAT-MSC supported mouse survival and facilitated post-infection wound healing by promoting re-epithelialization and vascularization. A transcriptomic profile analysis of oAT

Evidence level

Early human evidence such as case series or small samples is exploring possible benefits.

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