Polydeoxyribonucleotide improves scar healing following limited scar resection for chronic Achilles tendon rupture in a rat model

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Background Chronic Achilles tendon rupture (CATR) results from delayed diagnosis or treatment, leading to retracted tendon ends filled with biomechanically inferior scar tissue. Limited scar resection (LSR) offers a less invasive surgical option by preserving and repairing scar tissue between tendon stumps, but the quality of healing remains suboptimal. Polydeoxyribonucleotide (PDRN) has demonstrated pro-healing properties in tendon disorders, yet its effects on scar remodeling after LSR are unknown. Methods Chronic Achilles tendon rupture was induced in male Sprague-Dawley rats by full-thickness transection without repair and 4 weeks of unrestricted activity. Animals were randomized into four groups: normal, control (conservative treatment), LSR, and LSR+PDRN. Outcomes were assessed at 3 and 6 weeks post-intervention via macroscopical scoring, biomechanical testing (maximum load, stiffness, stress), histology (modified Movin score), and immunohistochemistry (COL I/III expression). Results Compared to conservative treatment, LSR technique demonstrated a faster recovery of maximum load to baseline levels, regardless of whether it was combined with PDRN adjuvant therapy. With PDRN supplementation, stiffness was also restored to baseline. Biomechanical outcomes improved throughout the healing process in all experimental groups, with the LSR+PDRN group exhibiting higher maximum loa

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

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