SVF
Level D· Preclinical EvidenceAnimal Study

Porous Se@SiO 2 nanoparticle composite hydrogels loaded with adipose stem cells improves the local microenvironment to promote rotator cuff tendon-bone healing in rats.

Dai X., Dang M., Meng X., Zheng J., Yang Y., Wang L.

Animal Study on Tendon Injury, Rotator Cuff, Chronic Wound, Chronic Inflammation, published in J Mater Chem B (2025) — summary generated from the PubMed abstract.

This page is generated from the PubMed record. The Thai description is an automated summary of bibliographic fields and the abstract, not a full translation, and is not medical advice.

Study type
Animal Study
Journal
J Mater Chem B (2025)
Country
England
Reported sample size
—
PMID
40259663
DOI
10.1039/d4tb02642j

Abstract (original English)

Functional repair of the tendon-bone interface poses significant challenges in clinical practice; furthermore, identifying methods to enhance healing at enthesis is a central concern in regenerative medicine. The application of stem cells in the healing process of interface injuries is widespread; however, direct injection of stem cells into this interface leads to significant losses of many stem cells. Oxidative stress significantly influences interface repair, and the role of selenium in mitigating oxidative stress and regulating inflammation has been demonstrated. This study utilised gelatine methacrylate (GelMA) as a stem cell transporter, while porous Se@SiO 2 nanoparticles (Se@SiO 2 NPs) were incorporated to change the interface microenvironment and facilitate the repair of the tendon-bone interface. Oxidative stress effects were analysed using flow cytometry, immunofluorescence staining, and qRT-PCR. The repair of the enthesis was assessed using histological staining, biomechanical evaluation, and MRI. Se@SiO 2 NPs significantly reduced the expression of inflammation-related markers in an in vitro oxidative stress model. Additionally, porous selenium nanocomposite hydrogels loaded with adipose stem cells were implanted into the rat tendon-bone interface. At eight weeks following the procedure, the enthesis exhibited superior collagen fibre continuity and orientation, enh

What this study does not prove

  • • This study does not prove SVF is an approved treatment or a replacement for standard care.
  • • This is preclinical work; animal or laboratory results cannot be applied to humans.

Evidence level

Evidence comes from animal or laboratory studies and has not been confirmed in humans.

How we grade evidence
AnimalsHydrogelsSilicon DioxideRatsPorosityNanoparticlesSeleniumStem CellsRats, Sprague-DawleyRotator Cuff
Face & SkinShoulderTendon InjuryRotator CuffChronic WoundChronic Inflammation
View on PubMedDOI

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