The potential role of silver nanoparticles in the tongue wound healing.

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

OBJECTIVES: The tongue is a complex muscular organ that can be affected by chronic ulcers and malignant tumors, which need proper management to improve healing and tissue regeneration. Hence, we aimed to assess the efficiency of adipose tissue stem cells (ADSCs) treated with/without silver nanoparticles (AgNPs) on tongue wound healing. MATERIALS AND METHODS: Fifty-six male white albino rats were divided into four groups; group I: tongue defects were prepared on the tongue dorsal surfaces using a tissue punch rotary drill for standardization, and were left untreated, group II: tongue defects were treated subepithelial using 2.5 µg/ml AgNPs solution using insulin syringe on the same day of defect preparation, group III: tongue defects were injected with 200 µl of ADSCs suspension (3.5 × 105 cells) and group IV: tongue defects were injected with 200 µl of ADSCs previously treated with 2.5 µg/ml AgNPs solution. Four- and seven-day follow-up following treatment, tongue specimens were collected, and histological assessment was conducted by hematoxylin and eosin (H&E) stain and immunohistochemical assessment of anti-TNF-alpha and anti-TGF-β, followed by histomorphometric assessment. Two-way ANOVA was utilized to compare between the groups after 4 and 7 days. RESULTS: The treated groups revealed a significant improvement characterized histologically by regenerated tissue with well-deve

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

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