Prognostic Value of Baseline and Soluble ST2 Change in Patients With Light Chain Cardiac Amyloidosis

Early human evidence such as case series or small samples is exploring possible benefits.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Background The prognostic significance of dynamic changes in soluble suppression of tumorigenicity-2 (sST2) in patients with light chain cardiac amyloidosis (AL-CA) remains unclear. We aimed to evaluate the prognostic significance of both baseline sST2 and 30-day changes (ΔsST2) in patients with light chain cardiac amyloidosis. Methods Patients diagnosed with light chain cardiac amyloidosis in Heart Failure Center, Fuwai Hospital (October 2015-May 2024) were enrolled in the entire cohort, with baseline sST2 measured. A prospective subcohort (October 2023-May 2024) also underwent 30-day repeat sST2 measurement. ΔsST2 was defined as the sST2 level at 30 days minus baseline sST2. The primary outcome was all-cause mortality. Prognostic value of both baseline and ΔsST2 was assessed using Kaplan-Meier and Cox models. The relationships between variables and primary outcome were examined with restricted cubic splines. Results In the entire cohort with 172 patients included (mean age 60.35±10.21 years; 40.1% women; median follow-up 310 days), higher baseline sST2 levels (>35 ng/mL) were independently associated with increased all-cause mortality risk (adjusted hazard ratio [HR], 1.82 [95% CI, 1.13-2.91], P 18 ng/mL) was also an independent indicator of worse prognosis (adjusted HR, 9.87 [95% CI, 1.90-51.11], P Conclusions Elevated baseline sST2 (>35 ng/mL) and short-term increases in sS

Evidence level

Early human evidence such as case series or small samples is exploring possible benefits.

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