Prophylactic Decellularized Adipose Matrix Treatment Mitigates Development of Radiation-Induced Cutaneous Fibrosis.

Early human evidence such as case series or small samples is exploring possible benefits.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Introduction Radiation therapy is an effective and common cancer therapy, but it often results in the formation of radiation-induced fibrosis (RIF). RIF of the skin manifests as symptoms including erythema, ulceration, hypovascularity, and poor wound healing. Subdermal injection of decellularized adipose matrix (DAM) has been studied as a potential means of correcting volumetric deficiencies while imparting regenerative effects to the overlying skin in patients with cutaneous RIF. Methods DAM was injected subdermally to the flank region of adult C57BL/6J mice and irradiation was then applied to this area. Irradiated mice were given 4 weeks after completion of the irradiation protocol to allow for development of chronic RIF. Magnetic resonance imaging studies were performed throughout the recovery interval to monitor volume retention of the product. Longitudinal laser Doppler studies were used to follow perfusion. After experimental completion, flank skin was harvested and underwent histological and biomechanical evaluation. Results Histological staining with hematoxylin and eosin, Masson's trichrome, and picrosirius red stains demonstrated that irradiated skin architecture more closely resembled normal skin across measures of dermal thickness, collagen density, and collagen organization when DAM was injected prophylactically. Magnetic resonance imaging revealed that DAM volume

Evidence level

Early human evidence such as case series or small samples is exploring possible benefits.

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