Protocol for preparation of a photo-triggering double cross-linked adhesive, antibacterial, and biocompatible hydrogel for wound healing

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

The treatment of full-thickness skin wounds represents a major clinical challenge, and hydrogel is regarded as a promising class of biomaterials for wound repair. Here, we present a protocol for preparing a photo-triggering double cross-linked, adhesive, antibacterial, and biocompatible hydrogel. We describe the steps to prepare the hydrogel and evaluate its mechanical performance, swelling kinetics, antibacterial property, biocompatibility in vitro, and therapeutic effect in vivo. This protocol is also applicable to other defect models of wound injury. For complete details on the use and execution of this protocol, please refer to our previous work. 1 .

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

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