Radiation-grafted poly(acrylic acid) on bacterial nanocellulose scaffolds modulates human adipose-derived stem cell morphology, proliferation, and extracellular matrix expression.

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Bacterial nanocellulose (BNC) is a promising biomaterial for wound healing due to its nanofibrillar architecture and high biocompatibility. In this study, BNC was produced using mango pulp waste as an alternative carbon source and subsequently modified through γ-radiation-induced grafting of poly(acrylic acid) (PAA) to alter its surface properties. Physicochemical characterization confirmed successful functionalization while preserving the native nanofibrillar structure, along with changes in hydration-related behavior consistent with increased surface polarity. The biological response of human adipose-derived mesenchymal stem cells (hADSCs) was evaluated in vitro. Compared with pristine BNC, the modified scaffolds were associated with changes in cell morphology, proliferation, and extracellular matrix (ECM)-related protein expression. In particular, pristine BNC supported greater cell spreading and proliferation, whereas BNC-g-PAA was associated with a distinct ECM-related profile. These findings suggest that γ-radiation-induced grafting can be used to)te the surface properties of BNC scaffolds and influence cell behavior. However, further studies are required to elucidate the contribution of grafting density, potential residual compounds from the carbon source, and long-term material-cell interactions. This work contributes to the development of sustainable, bioactive nanocel

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

Browse all related research

Filter the research library by this study's title keywords, author, or publication year.