Recent development of hydrogen sulfide-releasing biomaterials as novel therapies: a narrative review

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Hydrogen sulfide (H 2 S) has been reported as an endogenous gasotransmitter that contributes to the modulation of a myriad of biological signalling pathways, which includes maintaining homeostasis in living organisms at physiological concentrations, controlling protein sulfhydration and persulfidation for signalling processes, mediating neurodegeneration, and regulating inflammation and innate immunity, etc. As a result, researchers are actively exploring effective approaches to evaluate the properties and the distribution of H 2 S in vivo. Furthermore, the regulation of the physiological conditions of H 2 S in vivo introduces the opportunity to further study the molecular mechanisms by which H 2 S regulates cellular functions. In recent years, many H 2 S-releasing compounds and biomaterials that can deliver H 2 S to various body systems have been developed to provide sustained and stable H 2 S delivery. Additionally, various designs of these H 2 S-releasing biomaterials have been proposed to aid in the normal conduction of physiological processes, such as cardioprotection and wound healing, by modulating different signalling pathways and cell functionalities. Using biomaterials as a platform to control the delivery of H 2 S introduces the opportunity to fine tune the physiological concentration of H 2 S in vivo, a key to many therapeutic applications. In this review, we highli

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

Browse all related research

Filter the research library by this study's title keywords, author, or publication year.