Regenerative Aesthetics: Present Advances and Emerging Strategies for Optimized Tissue Health.

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Background The field of regenerative aesthetics is advancing rapidly, shifting from traditional cosmetic techniques to therapies targeting the biological mechanisms behind tissue degeneration. Objective The authors aimed to explore emerging therapies within the 3 pillars of regenerative aesthetics, cellular treatments, biochemical cues, and scaffolds highlighting recent advancements, regulatory challenges, and opportunities for further research. Methods A literature review was performed to identify clinical evidence for regenerative modalities in aesthetic practice, with 74 articles included for evaluation. Results The review covers adipocyte- and umbilical cord-derived stem cells and stromal vascular fraction (SVF) in aesthetic treatments. Nanofat, created through mechanical emulsification, shows promise by providing higher SVF yields while circumventing stricter regulations on enzymatic methods. Exosomes demonstrate therapeutic potential in wound healing, pigmentation disorders, and skin rejuvenation. Polydeoxyribonucleotides and polynucleotides exhibit significant tissue repair and anti-inflammatory effects; polynucleotides also serve as scaffolds for tissue volumization. In addition, new data suggest that poly- l -lactic acid promotes volumizing effects by increasing adipose-derived stem cells and remodeling the extracellular matrix. Conclusion Further research and regulato

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

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