Regenerative Biologics in Revision Rhinoplasty: Emerging Roles of Stem Cells, Nanofat, Platelet-Rich Plasma, and Exosomes in Soft Tissue Optimization and Healing.

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

• Level A · Stronger Clinical Evidence
• Level B · Emerging clinical evidence with positive signals
• Level C · Early human research exploring benefits
• Level D · Scientific groundwork from lab and animal studies
• Emerging · Emerging topic under active research

Abstract (original English)

Over the previous decade, regenerative medicine has been emerging as a new paradigm in facial plastic surgery in the treatment of skin quality and longevity. Its emergence has begun reshaping how we can approach complex nasal reconstruction and revision rhinoplasty, in particular, where vascular compromise, scarring, and contracture often limit traditional techniques and diminish results. Biologic adjuncts such as stem cells, nanofat, platelet-rich plasma, and exosomes are offering a way to complement mechanical derangement with cellular support.

Evidence level

Evidence from laboratory and animal studies provides groundwork for understanding mechanisms and potential before human studies continue.

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